The Adventures of Ozzie and Harriet is a long-running American sitcom, airing on ABC from October 3, 1952 to September 3, 1966, starring the real life Nelson family.

The series starred Ozzie Nelson and his wife, singer Harriet Nelson (née Hilliard), and their young sons, David Nelson and Eric Nelson, better known as Ricky. The series attracted large audiences, although it was never a top-ten hit, it became synonymous with the 1950s ideal American family life. It is the longest-running "live-action"/non-animated sitcom in US TV history.

Before the show aired, Ozzie Nelson persuaded ABC to agree to a 10-year contract that paid whether the series was canceled or not. The unprecedented contract and Ozzie's insistence for perfection in the show's production paid off in the show's remarkable popularity.

The Adventures of Ozzie and Harriet premiered on ABC on October 10, 1952, staying until September 3, 1966. The show strove for realism and featured exterior shots of the Nelsons' actual southern California home as the fictional Nelsons' home.

Interior shots were filmed on a sound stage recreated to look like the real interior of the Nelsons' home. Like its radio predecessor, the series focused mainly on the Nelson family at home, dealing with run-of-the-mill problems. As the series progressed and the boys grew up, storylines involving various characters were introduced.

Many of the series storylines were taken from the Nelsons' real life. When the real David and Rick got married, to June Blair and Kristin Harmon respectively, their wives joined the cast of Ozzie and Harriet, and the marriages were written into the series.

By the mid 1960s, America's social climate was changing, and the Nelsons' all American nuclear family epitomised the 1950s values and ideals that were quickly becoming a thing of the past.

Ozzie, who wrote and directed all of the series' episodes, attempted to change with the times, but most viewers related the show to a long gone era. The show made the transition from black-and-white to colour in its 1965–66 season, but ABC canceled Ozzie and Harriet in 1966.

A number of actors had supporting roles on Ozzie and Harriet, including Jimmy Hawkins, Don DeFore, Mary Jane Croft, Lyle Talbot, Frank Cady, Skip Young, and Kent McCord.