Ray Charles Robinson was born, the son of Aretha Williams, who stacked boards in a sawmill, and Bailey Robinson, a railroad repair man, mechanic and handyman. The two were never married. The family moved to Greenville, Florida, when Ray was an infant. Bailey had three more families, leaving Aretha to raise the family on her own. When Charles was five, he witnessed his younger brother, George, drown in a large portable laundry tub.

Ray Charles began to go blind when he was five. He became totally blind by the age of seven. Charles never knew exactly why he lost his sight, though there are sources which suggest his blindness was due to glaucoma, and some other sources suggest that Ray began to lose his sight from an infection caused by soapy water to his eyes which was left untreated. He attended school at the St. Augustine School for the Deaf and the Blind in St. Augustine, Florida. He also learned how to write music and play various musical instruments. While he was there, his mother died followed by his father two years later.

Before he left school, Charles began working as a musician in many bands that played in various styles, including jazz and, in Tampa “with a hillbilly band called The Florida Playboys." This is where Charles began his reputation of always wearing sunglasses.

Charles moved to Seattle in 1947. He soon started recording, first for the label Swingtime Records, achieving his first hit with "Confession Blues", recorded in 1949. The song hit #2 on the R&B charts. He followed his first recording with his only other hit with Swingtime, "Baby, Let Me Hold Your Hand" in 1951. It hit #5 on the R&B charts. He then signed with Ahmet Ertegün at Atlantic Records a year later. When he entered show business, his name was shortened to Ray Charles to avoid confusion with opera star boxer Sugar Ray Robinson.

Almost immediately after signing with Atlantic, Charles scored his first hit singles with the label with "It Should Have Been Me" and the Ertegun-composed "Mess Around", both making the charts in 1953. But it was Charles' "I Got A Woman" (composed with band mate Renald Richard) that brought the musician to national prominence.

The song reached the top of Billboard's R&B singles chart in 1955 and from there until 1959, Charles would have a series of R&B chart-toppers including "This Little Girl of Mine", "Lonely Avenue", "Mary Ann", "Drown in My Own Tears" and "The Night Time (Is the Right Time)", which were compiled on his Atlantic releases Hallelujah, I Love Her So, Yes Indeed!, and The Genius Sings the Blues.

During this time of transition, he recruited a young girl group from Philadelphia named the Cookies as his background singing group, recording with them in New York and changing their name to the Raelettes in the process. Former record producer Joel Dorn often wrote letters to Nesuhi Ertegun telling them that he should do a duet.

In 1959, Charles crossed over to top 40 radio with the release of his impromptu blues number, "What'd I Say", which was initially conceived while Charles was in concert. The song would reach number 1 on the R&B list and would become Charles' first top ten single on the pop charts, peaking at number 6. Charles would also record The Genius of Ray Charles, before leaving Atlantic for a more lucrative deal with ABC Records in 1959.

Hit songs such as "Georgia On My Mind" (US #1), "Hit the Road Jack" (US #1) and "Unchain My Heart" (US #9) helped him transition to pop success and his landmark 1962 album, Modern Sounds in Country and Western Music and its sequel Modern Sounds in Country and Western Music, Vol. 2, helped to bring country into the mainstream of music. He also had major pop hits in 1963 with "Busted" (US #4) and "Take These Chains From My Heart" (US #8).