Serena Harriet Scott Thomas is an English actress. Scott Thomas was born in Nether Compton, Dorset. Her mother, Deborah (née Hurlbatt), was raised in Hong Kong and Africa, and studied drama before marrying Scott Thomas' father.

Her father, Lieutenant Commander Simon Scott Thomas, was a pilot for the British Royal Navy who died in a flying accident in 1964. She is the younger sister of actress Kristin Scott Thomas, the niece of Admiral Sir Richard Thomas (who was Black Rod in the House of Lords), and a more distant grand niece of Capt. Robert F. Scott, the ill-fated explorer who lost the race to the South Pole. Her last name is an amalgam of the last names of those two families.

Thomas is known for her portrayal of the character Dr. Molly Warmflash in the 1999 James Bond film The World Is Not Enough as well as appearing in the 1993 TV film Harnessing Peacocks, based on the novel by Mary Wesley. She appeared as Gwendolyn Post on a (Season #3) episode of Buffy the Vampire Slayer called Revelations.