The best known chemistry sets were produced by the A. C. Gilbert Company, an early and middle 20th century American manufacturer of educational toys. Chemcraft and the Skilcraft corporation were other manufacturers.

Concerns have been raised over the safety of chemistry sets, so many omit flammable chemicals, or else contain them in such small amounts that they pose relatively little danger. Likewise, they may also lack heat sources, breakable glass, and strong acids and bases.

There has also been controversy over the possibility of chemistry sets being used to create illegal drugs, such as methamphetamine. Many experts criticise these movements, claiming that they "remove the fun and interest" from chemistry, rendering the sets bland and ineffectual.

Chemistry sets are still available to buy today, but don't expect to see the lethal concoctions of the past included. It's all a much safer affair now.